Page 85 - Bladder Dysfunction in the Context of the Bladder-Brain Connection - Ilse Groenendijk.pdf
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                 Single subject and group whole-brain fMRI mapping of male genital sensation at 7 Tesla 83 Table 1. Whole-brain group activation in response to stimulation of the penile shaft and feet versus rest
 Region
 Hemisphere
 Penile shaft
 Foot (left)
 Foot (right)
 x
 y
 z
 t-value
 x
 y
 z
 t-value
 x
 y
 z
 t-value
 superomedial S1
 L
 -18
 -38
 68
 3.39
     -4
 -38
 72
 7.90
R
18
-40
68
3.77
6
-36
70
6.36
18
-40
68
6.07
S2
L
-42
-30
-22
4.13
-48
-36
26
4.36
-44
-30
20
5.39
R
40
-30
24
6.19
46
-30
24
5.17
42
-30
22
5.26
inferolateral S1
L
-58
-16
34
6.57
-62
-16
36
5.63
R
56
-18
32
4.38
vPMC
L
-58
6
32
3.42
R
56
6
28
3.66
posterior insula
L
-36
-16
16
3.13
-36
-18
16
6.74
R
40
-12
14
4.33
34
-14
16
9.04
36
-16
16
5.93
anterior insula
L
-36
0
12
2.66
R
36
2
14
3.05
pMCG
L
-12
-24
42
2.12
R
mPFC
L
-4
52
26
1.89
R
12
60
28
1.81
thalamus
L
-12
-6
8
2.25
-22
-24
12
5.30
R
18
-22
4
1.68
22
-22
12
4.70
16
-22
12
3.71
cerebellum
 L
-26
-54
-26
2.35
-14
-36
-22
5.09
R
 20
 -62
 -24
 2.73
     20
 -34
 -26
 4.11
    Table 1. Brain regions, MNI coordinates and peak t-values are listed. All activation for the penile shaft is re- ported using a global null conjunction analysis (p < 0.005 uncorrected for multiple comparisons, t-value > 1.52). All activation for the left and right feet are reported using a one sample t-test (p < 0.005 uncorrected for multiple comparisons, t-value > 3.05). S1: primary somatosensory cortex; S2: secondary somatosensory cortex; vPMC: ventral premotor cortex; pMCG: posterior midcingulate gyrus; mPFC: medial prefrontal cor- tex.
Functional Connectivity
We also assessed the functional connectivity between timeseries of regions of interest (ROIs) for both functional tasks separately (Fig. 4 and Fig. 5). For the penile shaft, time- series from the superomedial and inferolateral S1, S2, vPMC, posterior insula and the right anterior insula showed moderate correlation (range ρ 0.44 - 0.60). The left anterior insula showed weak correlation (range ρ 0.36 - 0.49) with the superomedial and inferolateral S1, S2, vPMC and posterior insula. Timeseries from the pMCG and cerebellum showed weak correlations overall with other ROIs.
For the left foot, timeseries from superomedial S1 in the right hemisphere showed a strong correlation with the S2 and posterior insula ROIs on the same side, whereas correlation with S2 in the left hemisphere was weaker (Fig. 5A). Timeseries from the
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