Page 83 - Bladder Dysfunction in the Context of the Bladder-Brain Connection - Ilse Groenendijk.pdf
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                 Single subject and group whole-brain fMRI mapping of male genital sensation at 7 Tesla 81
  Figure 1. Single subject cortical activation patterns. Single subject activation maps (p < 0.05 FWE) from all individuals (n=13) displayed on inflated anatomical images showing top-view. Legend in bottom-right corner indicating task specific color codes.
Whole-brain results
To further determine which cortical areas are implicated in processing tactile input from the genitalia and the feet outside of S1, we also examined whole-brain responses (Table 1). Tactile stimulation of the penile shaft elicited bilateral activations in S2, posterior and anterior insula, vPMC and the cerebellum. In single subjects, unilateral and bilateral acti- vations were seen in the pMCG, mPFC and thalamus. At group level, unilateral activation in the pMCG was seen in the left hemisphere and bilateral activation was seen in the mPFC. We also observed subcortical activation in the medial and posterior regions of the thalamus, correlating with reported locations of the medial dorsal (MD) and ven- tral posterolateral (VPL) nuclei.20,21 Tactile stimulation of the left foot elicited bilateral activations in S2, unilateral activation in the posterior insula in the right hemisphere, and unilateral activation in the cerebellum in the left hemisphere. Subcortical activation was observed posterior in the thalamus in the right hemisphere, presumably the VPL. Tactile stimulation of the right foot elicited bilateral activations in S2, posterior insula, and unilateral activation in the vPMC in the left hemisphere. Subcortical activation was observed posterior in the thalamus (VPL) in both hemispheres.
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