Page 106 - Coronary hemodynamics in acute myocardial infarction - Matthijs Bax

Chapter 6
A
B
Figure. Kaplan Meier estimates and log rank comparison of cumulative fatal events. Log rank comparison of Kaplan Meier estimates resulted in a significant difference in A) all-cause mortality, as well as B) cardiac mortality, between normal and abnormal reference vessel coronary flow velocity reserve.
Discussion
In our study population, we observed that an abnormal reference vessel CFVR of ≤2.7 was associated with a 2.24-fold increase in hazard for long-term all- cause mortality after multivariable adjustment. Twelve-year Kaplan–Meier estimates of all-cause mortality amounted to 16.7% when reference vessel CFVR was normal, in contrast to 39.6% in the presence of an abnormal reference vessel CFVR. In addition, abnormal reference vessel CFVR was associated with a 3.32-fold increase in hazard for long-term cardiac mortality. The impairment in reference vessel CFVR was found to originate from a significantly higher baseline APV in the presence of a significantly lower baseline microvascular
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