Page 129 - Helicobacter pylori and Gastric Cancer: From Tumor microenvironment to Immunotherapy
P. 129

 Abstract
Background: Although the causal relationship between Helicobacter pylori- infection and the development of gastric cancer is firmly established, the exact nature of the virulence factors of H. pylori that predispose to gastric oncogenesis remains incompletely characterized. Such knowledge would aid stratification of H. pylori-infected individuals with respect to their risk to GC. We decided to investigate the association between H.pylori virulence genotypes and disease in a well-characterised cohort consisting of 109 H.pylori isolates from gastric biopsies originating from patients. Methods: The prevalence of genotype was assessed by PCR and related to clinical histopathological parameters. Results: We were able to identify association between genotypes and clinical outcome. The relation of babA2, babB negative and iceA1 positive genotype as a single genotype and the development of cases to GC (Signet Ring Cell Carcinoma) was statistically significant (P <0.001).The cagE, cagA, iceA1 were found more commonly in patients with GC as compared with the other patient groups. The relation of the presence of iceA1 and the development of cases to GC was statistically significant (P=0.008), but babA2, babB alleles were not detected in these GC patients. These apparent negative association were still statically significant (P=0&0.005). Conclusion: Our results show an elevated prevalence of infection with H. pylori strains carrying known virulence genotypes with high genetic diversity. This highlights the importance of identifying gene variants for an early detection of virulent genotypes. Also, the results identify H. pylori genotypes associated with clinical outcome that may become potentially useful for patient risk stratification for GC.
Keywords: Helicobacter pylori, pathogenicity factors, gastric cancer
                                  H-pylori pathogenicity factors H.pylori pathogenic factors
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