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                                Chapter 6
 Heritability of Subcortical-Subcortical Connectivity
An overview of ACE models for limbic/subcortical-cortical brain connectivity between seed (VS and AMY) and the subcortical ROIs (HPC, TH, AMY) is provided in in Table 6. Comparisons of the full ACE model with more parsimonious AE, CE and E models are displayed in Table S9. Note that the estimates of the different components add up to 1 (100%). Subcortical-subcortical connectivity was moderately influenced by genetics, with A estimates ranging from 32-42% (VS- HPC A=37%, E=63%; VS-AMY A=42%, E=58%; AMY-HPC A=32%, E=68%; AMY-TH A=35%, E=65%), and no influence of the shared environment (C=0%), with the exception of VS-TH connectivity, which was mostly influenced by environmental factors (A=4%, C=15%, E=81%), see Table 6.
Table 4. Mean and standard deviations of Z-values for all subcortical-cortical and subcortical-subcortical connectivity patterns. Differences in connectivity patterns from ventral striatum and amygdala were tested with paired sample T- tests.
ROI Sample
vmPFC Sample I Sample II
vACC Sample I Sample II
OFC Sample I Sample II
dmPFC Sample I Sample II
dACC Sample I Sample II
dlPFC Sample I
Sample II Thala- Sample I
mus Sample II Hippoc Sample I ampus Sample II
VS mean (SD)
1.66 (1.34) 1.69 (1.60) 1.05 (1.04) 0.86 (1.14) 1.31 (0.88) 1.09 (0.89) -0.29 (0.61) -0.05 (0.54) -0.54 (1.03) -0.73 (1.21) -0.48 (0.59) -0.31 (0.55)
0.51 (1.37) 0.50 (1.37) -0.52 (1.87) -0.41 (2.10)
AMY mean (SD)
-0.04 (1.45)
0.26 (1.03)
-0.25 (0.93)
0.06 (0.86)
1.13 (1.11)
1.28 (0.76)
-0.75 (0.62)
-0.72 (0.59)
-0.38 (1.11)
-0.29 (1.14)
-0.88 (0.67)
-0.88 (0.54) -0.43 (1.47) -0.15 (1.32) 6.67 (1.93) 6.43 (2.17)
Statistics
t(77)= 8.19
t(77)=7,33
t(77)=7,33
t(77)=5,37
t(77)=1,21
t(77)=-1,70
t(77)=4,93
t(77)=7,70
t(77)=-,89
t(77)=-2,49
t(77)=4,05
t(77)=7,01 t(77)=3,53 t(77)=2,92 t(77)=-21,87 t(77)=-18,49
p
<.001
<.001
<.001
<.001
.229
.093
<.001
<.001
.379
<.001
<.001
<.001 .001 .005 <.001 <.001
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