Page 14 - Improved endothelialization by silicone surface modification and fluid hydrodynamics modulation- Implications for oxygenator biocompatibility Nasim

formation. Our results showed that nitrite bioavailability has a direct effect on thrombus deposition on surface-modified fibers under shear stress.
Coating of fibers with nNitrite-nGH-Col conjugate not only increased endothelial cell proliferation and stability, but also increased nitrite bioavailability and inhibited thrombus formation even under high shear stress, suggesting that this conjugate coating is highly promising to improve the biocompatibility of biohybrid artificial lungs. This, together with new insights in the effects of fluid shear stress on increasing cell stability, and anti-thrombotic functionality, as well as on modifying the bioavailability of anti-thrombotic biomolecules and thrombus deposition, improves our understanding of how surface modification and fluid hydrodynamics modulation increase material biocompatibility under flow condition. These insights could contribute to the development of biocompatible silicone to use in biohybrid artificial lungs and other blood-contacting devices.