Page 27 - EVALUATION OF TREATMENT FOR HEAVY MENSTRUAL BLEEDING by Herman, Malou

Pictorial Blood Assessment Chart and endometrial ablation outcome
The ROC curve for satisfaction had an AUC of 0.93 (Figure 3). At PBAC12m the best cutoff score is 59 points, with a sensitivity and specificity of 0.85 and of 0.84, respectively. The sensitivity analysis shows similar results (AUC=0.93, sensitivity=0.84, specificity=0.83). For re-intervention, the ROC is comparable. The AUC is equal to 0.91 (Figure 4). The best cut-off value for PBAC12m is 98 points, with sensitivity of 0.82 and specificity of 0.85. After correction for study, the best cut-off value increases to 128 points, AUC to 0.94, sensitivity to 0.89 and specificity to 0.86. The sensitivity and specificity of different PBAC12m scores are given in table 2.
Table 2: Sensitivity and specificity for some specific PBAC12m scores regarding satisfaction and re- intervention
0 0.00 100 100 32
PBAC score
Sensitivity %
satisfaction
Specificity %
satisfaction
Sensitivity %
re-intervention
Specificity %
re-intervention
20 70 93 40 78 89 50 82 87 59* 85 84
95 57
91 66
89 71
- -
87 75
84 80
82 85 80 85
76 89 76 90 76 91 76 92 71 92 66 93 - -
9 100
60 85 80 90
98** - 100 93
120 95 140 96 150 96 160 97 180 97 200 98 413 100 1150 -
83 78
.- 78
74 73 72 70 69 64 45 -
7
PBAC = Pictorial Blood Assessment Chart
* Best cutoff point in ROC for satisfaction
** Best cutoff point in ROC for re-intervention.
Percentage of change in PBAC
The percentage change in PBAC score is also strongly associated to satisfaction (OR 2.0 [95%CI 1.7-2.3]) and surgical re-intervention (OR 0.69 [95%CI 0.63-0.75]). The ROC curve for satisfaction is shown in Figure 5, where the AUC is 0.92. The best
89