Page 308 - Prevention and Treatment of Incisional Hernia- New Techniques and Materials

Chapter 15
Results
Mesh infection
During the experiment 8 animals were euthanized due to clinically evident mesh infection with transcutaneous migration of the prosthesis between day 49 and 87. In all euthanized rats, 7 animals of the CollamendFM group and 1 of the Surgisis group, necropsy was performed and large mesh abscesses were found intra abdominally. In total 15 of 64 rats (23.4%) were found to have macroscopic infection of the mesh at time of sacri ce. In Figure 1 the amount of mesh infections per mesh-group is shown. Strattice had a signi cantly lower number of mesh infections compared to CollamendFM at 90 days (P<0.001). At 180 days CollamendFM showed a signi cantly higher rate of mesh infection compared to all other meshes (P<0.004). Maximum percentage of weight loss was signi cantly higher in CollamendFM compared to all other groups (median 6, compared to Strattice 2; Surgisis 3; Permacol 3.5, P=0.001).
Mesh incorporation
Animals with mesh infection were not included in this analysis because no incorporation of the mesh was found in these animals. Incorporation of the meshes was not signi cantly di erent between the groups at 90 days (median 13.2%, IQR 0-24.2%). Data per mesh is shown in Figure 2. No Surgisis meshes could be identi ed at 180 days and incorporation was scored as 0%. Therefore at 180 days the incorporation of Surgisis (0%, 0-0) was signi cantly lower than Strattice (13.7%, 10.3-22.4; P<0.001) and Permacol (20.7%, 5.7-24.5; P<0.001). For each mesh no di erence in incorporation of the mesh was observed between 90 and 180 days.
Adhesions
At 90 days Surgisis had the highest percentage of mesh adhesions to the mesh implantation site (90%, 32.5-100) which was signi cantly more than all other meshes (P<0.023). Data per mesh is shown in Figure 3. Strattice showed a signi cantly smaller percentage of mesh surface covered with adhesions (5.0%, 5.0-5.0; median Zühlke 2) compared to all other meshes (P<0.029). When only considering non-infected meshes there was no longer a di erence in adhesion coverage between Strattice and CollamendFM .
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