Page 304 - Prevention and Treatment of Incisional Hernia- New Techniques and Materials

Chapter 15
Abstract
Background
This study investigates long-term incorporation, adhesion formation, mesh infection and shrinkage after implantation of biological meshes in non- contaminated environment.
Methods
In 64 rats a mesh-model was used to implant various meshes intraperitoneally: 2 non-crosslinked mesh groups (Strattice and Surgisis) and 2 crosslinked mesh groups (CollaMendFM and Permacol). Sacri ce was after 90 and 180 days.
Results
High numbers of infectious complications were observed (12.5% transcutaneous prosthesis migration and 23.4% macroscopic mesh infection). Incorporation of meshes was poor (0% to 36.8%) on POD 180. Mesh shrinkage was highest in Surgisis (POD 90 57%, P<0.01). On POD 180, shrinkage did not di er between the meshes. Surgisis had the highest adhesion score on POD 90 (90%, P<0.023). Adhesions covering the mesh was least in Strattice (5%, P<0.029).
Conclusions
Experimental intraperitoneal implantation of biological meshes is accompanied by various infectious complications with little incorporation and will most likely not adequately prevent the formation of recurrent incisional hernia.
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