Page 286 - Prevention and Treatment of Incisional Hernia- New Techniques and Materials

Chapter 14
Abstract
Background
This experimental study investigates infectious complications and functional outcome of biological meshes in a contaminated environment.
Methods
In 90 rats peritonitis was induced, and after 24 hours, a biological mesh was implanted intraperitoneally including 2 non-crosslinked mesh groups (Strattice and Surgisis) and 2 crosslinked mesh groups (CollaMendFM and Permacol). Sacri ce was after 90 and 180 days.
Results
More mesh infections occurred in crosslinked meshes compared with non- crosslinked meshes (70% vs 4%; P < 0.001). Mesh infection was the highest in crosslinked CollaMendFM (81.2%) and lowest in non-crosslinked Strattice groups (0%). Incorporation into the abdominal wall was poor in all meshes (0% to 39%). After 180 days no residue of non-crosslinked Surgisis mesh was found. After 180 days, shrinkage was 0.8% in crosslinked Permacol and 20% in Strattice groups. Strattice showed the least adhesion formation (median 5%).
Conclusions
Infection rate of biological meshes in a contaminated eld was the highest in crosslinked meshes. All biological meshes showed poor incorporation, which makes long-term abdominal wall repair questionable.
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