Page 241 - Prevention and Treatment of Incisional Hernia- New Techniques and Materials

Meshes in a contaminated environment
without cellular in ltration into it. A large number of vessels could be seen in the tissue surrounding Parietene Composite® and Omyramesh®. Because of wide intra-animal variation, no statistically di erence was found for brosis, in ux of lymphocytes, angiogenesis and collagen deposition (data not shown).
Figure 4. Histological samples after 90 days: a,c,e,g,i haematoxylin and eosin staining and b,d,f,h,j picrosirius red staining of histological samples after 90 days (original magni cation ×40). a,b Polypropylene (Parietene®; Sofradim, Trevoux, France; part of Covidien, North Haven, Connecticut, USA); c,d collagen–polyethyleneglycol–glycerol-coated polypropylene (Parietene Composite®; Sofradim); e,f carboxymethylcellulose–sodium hyaluronate-coated polypropylene (Sepramesh®; Bard, New Providence, New Jersey, USA); g,h expanded polytetra uoroethylene (Dualmesh®; Gore, Flagsta , Arizona, USA); i,j condensed polytetra uoroethylene (Omyramesh®; B. Braun, Melsungen, Germany); and k,l non-cross-linked collagen mesh (Strattice®; LifeCell, Branchburg, New Jersey, USA). The purple and pink cells in the haematoxylin and eosin-stained sections are broblasts and lymphocytes. The synthetic bres of the Parietene® (a,b), Parietene Composite® (c,d), Sepramesh® (e,f) and Omyramesh® (i,j) are surrounded with brotic tissue with newly formed collagen. Around Dualmesh® (g,h) a cellular layer is observed, forming a capsule; cellular in ltration into the mesh is minimal. In the picrosirius red- stained section of the Strattice® mesh (l) it is impossible to di erentiate between the collagen of the mesh and newly formed collagen (C/F). M, abdominal wall muscle; F, mesh bres, C, newly formed collagen layer.
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