Page 31 - Pro-active Management of Women’s Health after Cardiometabolic Complicated Pregnancies

Table 2.1.2. Characteristics of women with full follow-up data and lost-to-follow-up with regard to blood pressure measurements
Gestational age at diagnosis (weeks) Prolongation of preeclampsia (days) Maximal systolic blood pressure during preeclampsia (mmHg) Maximal diastolic blood pressure during preeclampsia (mmHg) Maximal level of proteinuria
110 (90-145) 4.0 (0.3-25.3) 82 (45-626)
31 (25-41) 0.02 14 (0-62) 0.01
180 (130-280) 0.001 115 (90-170) 0.02 5.4 (0.3-31.4) 0.09 84 (52-394) 0.19
during preeclampsia (gr/24h)
Maximal level of creatinine
during preeclampsia (mmol/l)
Values are presented as median(range) and compared using Mann-Whitney tests.
2.1 Resolution of hypertension and proteinuria| 29
Complete Data n=116
32 (21-42)
6 (0-60) 170 (130-226)
Lost-to-follow-up n=89
p-value
interval. At discharge after delivery 78% still had hypertension. At six weeks postpartum in 54%, and at three months postpartum in 39% of the women hypertension was still present. Finally, at two years postpartum 18% had persistent hypertension. No difference was observed in normalization between primiparous and multiparous women. In the AFT-model, both a higher maximal systolic blood pressure and higher maximal diastolic blood pressure during preeclampsia increased resolution time (resp. p<0.001 and p=0.044). Also, longer time interval between diagnosis and delivery increased resolution time (p=0.001). Figures 2.1.2, 2.1.3 and 2.1.4 show the effect of these variables on the resolution curve. The baseline in each figure is defined as maximal systolic blood pressure of 140 mmHg, maximal diastolic blood pressure of 90 mmHg and time interval between diagnosis and delivery of 0 days. The curves show the effect on the rate of resolution of hypertension when the specific variable changes, leaving the other variables at baseline. The coefficients for the corresponding AFT-model are presented in table 2.1.3. Resolution time of hypertension was not significantly correlated with the maximum level of proteinuria and gestational age at onset of preeclampsia.