Page 158 - Pro-active Management of Women’s Health after Cardiometabolic Complicated Pregnancies

156 | Part 3 Lifestyle intervention
growth restriction have not been evaluated yet204.
The primary aim of this study is to evaluate the feasibility of a lifestyle
intervention program after complicated pregnancies associated with an increased risk of future cardiometabolic disease by comparing the proportion of eligible women who completed the intervention to other lifestyle intervention programs. Secondary aim is to test effectiveness of this intervention in improving maternal cardiometabolic risk factors by analysing change in weight and other cardiometabolic risk factors before and after the intervention.
MATERIALS AND METHODS
The Postpartum Rotterdam Appraisal of Cardiometabolic health and Tailored Intervention (PRo-ACTIve) study is a feasibility study to develop and evaluate a postpartum lifestyle intervention program. It was designed as a multicentre, specific pre-post controlled study268 to develop and evaluate the lifestyle intervention. During the first year of the study a control cohort was considered to be a vital part of the effect evaluation of the intervention.
Women with pregnancies complicated by preeclampsia, fetal growth restriction and/or gestational diabetes mellitus were included between February 2007 and September 2010. Preeclampsia was defined according to ISSHP- criteria5: blood pressure of 140/90 mmHg or higher and proteinuria of at least 300 mg/day after a gestational age of at least 20 weeks. Severe preeclampsia was defined according to ACOG-criteria83: a blood pressure of 160 mmHg systolic or higher or 110 mmHg diastolic or higher; proteinuria of 5 gram or more in a 24- hour urine specimen or dipstick urinalysis of 3+ or greater in two random urine samples collected at least 4 hours apart; cerebral or visual disturbances; elevated liver enzymes; thrombocytopenia; fetal growth restriction. Fetal growth