Page 77 - Development of Functional Scaffolds for Bone Tissue Engineering Using 3D-Bioprinting of Cells and Biomaterials - Yasaman Zamani

CONCLUSION
Forces induced to the mandibular symphysis during opening and closing of the jaw were predicted using our dynamic biomechanical model. This model can also be extended to prediction of forces during other functions such as mastication at any other part of the mandible. Mechanical properties of the 3D-printed PCL scaffolds were tailored based on the predicted forces on mandibular symphysis. Mechanical properties of the 3D-printed PCL scaffolds were different in scaffold building direction compared with the side direction. This should be taken into account when placing the scaffold in the defect site. Our findings might have implications for improved performance and integration of scaffolds with native tissue.
AKNOWLEDGEMENTS
The authors wish to extend their thanks to Prof. Cornelis J. Kleverlaan (Academic Centre for Dentistry Amsterdam) for his valuable inputs in mechanical testing of the scaffolds. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
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