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Printing of this thesis was financially supported by Astellas Pharma B.V, Amgen B.V., Celgene B.V., Gilead Sciences Netherlands B.V., Pfizer B.V., Roche Nederland B.V.
ISBN: 978-90-6464-906-6
Lay out: Ferdinand van Nispen, Citroenvlinder DTP&Vormgeving, my-thesis.nl,
Bilthoven, The Netherlands
Cover: M.J. Wondergem, Hanoi november 2013
Printed by: GVO drukkers & vormgevers B.V. | Ponsen & Looijen, Ede, The Netherlands
Copyright © 2015 M.J. Wondergem, Amsterdam, the Netherlands


































































































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