Page 89 - Recognizing axial spondyloarthritis - Janneke de Winter
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ANTI-CD74 ANTIBODIES IN EARLY AXIAL SPA
based settings. In the latter settings however, the pretest probability would be much lower and consequently, the performance of the test would even be worse.
Conclusion
We conclude that anti-CD74 IgG and IgA antibodies are of limited value in diagnosing axSpA in patients with early, chronic back pain. Long-term follow-up of the patients of the SPACE cohort will show whether anti-CD74 IgA antibodies contribute to predicting certain axSpA characteristics such as radiographic damage, extra-articular manifestations, or peripheral joint disease.
Acknowledgements: We acknowledge M.C. Turina for her help in this study. DB was supported by a VICI grant from The Netherlands Organization for Scientific Research (NWO), by an ERC grant and by a grant from the Dutch Arthritis Foundation (Reumafonds).
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