Page 18 - ADULT-ONSET ASTHMA PREDICTORS OF CLINICAL COURSE AND SEVERITY

ADULT-ONSET ASTHMA – PREDICTORS OF CLINICAL COURSE AND SEVERITY
data was pooled with two other clinical trials with similar methodologies. Together, these three cohorts consisted of 571 pa ents with adult-onset asthma.
The outline of the thesis is as follows: at rst, Chapter 2 gives an overview of all the studies about prognosis of adult-onset asthma. Therea er, Part 1 focusses on the accuracy of biomarkers of airway in amma on and serves as a method check. Chapter 3 addresses biomarkers of eosinophilic airway in amma on in di erent adult asthma phenotypes, based on the combined cohort data. Chapter 4, describes a systema c review and meta-analysis to iden fy and pool all studies about biomarkers of airway eosinophilia in asthma pa ents. Consecu vely, Part 2 of this thesis addresses the clinical course of adult-onset asthma. The data of the Adonis-study was used in Chapter 5 to describe predictors of asthma remission and persistence and in Chapter 6 to describe predictors of increased asthma severity. In Chapter 7 the combined cohort was used to inves gate whether predictors of frequent asthma exacerba ons are di erent in smokers and never-smokers.
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