Page 93 - THE EVOLUTION OF EARLY ARTHRITIS AND CARDIOVASCULAR RISK Samina A. Turk

AN UNFAVORABLE BODY COMPOSITION
Tri- glycerides, mmol/l†
HDL, mmol/l†
LDL, mmol/l†
TChol: HDL ratio†
FMI
2.09
(0.27-3.91) 0.025*
-3.11
(-6.22-0.01) 0.050
0.55
(-0.86-1.95) 0.437
1.04
(0.25-1.82) 0.011*
Percentages of fat distributed to the trunk
5.81 (3.29-8.34) <0.001*
-4.53
(-9.17-0.12) 0.056
2.23
(0.24-4.21) 0.028
1.96
(0.82-3.10) 0.001*
Android to gynoid ALMI fat mass ratio
0.15 -0.10
(0.07-0.22) <0.001* (-0.60-0.39) 0.677
-0.15 -0.23
(-0.28- -0.01) 0.040 (-1.07-0.60) 0.577
0.08 0.07
(0.02-0.14) 0.007* (-0.30-0.43) 0.723
0.06 0.10 4 (0.03-0.10) <0.001* (-0.11-0.32) 0.351
ALMI: appendicular lean mass index, B: beta (1 point increase in blood pressure or lipid profile is X change in FMI, percentages of fat distributed to the trunk, android to gynoid fat mass ratio or LMI), BP: blood pressure, CI: confidence interval, FMI: fat mass index, HDL: high-density lipoprotein, LDL: low-density lipoprotein, mmHg: millimetre mercury, mmol/l: millimole/liter, NSAID: non-steroidal anti-inflammatory drugs, TChol: total cholesterol ‡Patients without antihypertensives
†Patients without statins
*significant results at the 0.05 false discovery rate for 56 tests
S2 Table. Linear regression analyses between disease activity and body composition in early arthritis patients, stratified for gender and corrected for age and smoking status
FMI Percentages of fat Android to gynoid ALMI distributed to the fat mass ratio
trunk
Females, B B B B
n=220
ESR in mm/ hour (me- dian, IQR)
DAS28 (mean, SD)
SJC38 (me- dian, IQR)
TJC38 (me- dian, IQR)
RF positive (n,%)
ACPA posi- tive (n,%)
(CI) and p-value
0.04
(0.00-0.07) 0.028
0.33
(-0.17-0.83) 0.194
-0.09
(-0.20-0.01) 0.089
0.06
(-0.03-0.15) 0.204
0.44
(0.99-1.87) 0.546
-0.04
(-1.49-1.42) 0.963
(CI) and p-value
0.01
(-0.03-0.04) 0.797
-0.39
(-0.98-0.20) 0.190
-0.13
(-0.26- -0.01) 0.040
-0.03
(-0.14-0.07) 0.534
0.43
(-1.27-2.13) 0.616
0.89
(-0.83-2.61) 0.310
(CI) and p-value
<0.01
(0.00-0.00) 0.861
-0.01
(-0.02-0.01) 0.343
<0.01
(-0.01-0.00) 0.030
<0.01
(0.00-0.00) 0.894
0.02
(-0.02-0.06) 0.400
0.02
(-0.02-0.06) 0.389
(CI) and p-value
<0.01
(1.1-1.01) 0.387
-0.01
(-0.10-0.081) 0.869
-0.01
(-0.03-0.01) 0.195
<0.01
(-0.01-0.05) 0.403
0.03
(-0.22-0.28) 0.812
-0.07
(-0.33-0.19) 0.238
table continues
91