Page 17 - Fluorescence-guided cancer surgery

using a low-dose of ICG. Chapter 6 shows the intraoperative detection of a paraganglioma and otherwise undetectable local metastases using MB. Chapter 7 reports the detection of parathyroid adenomas and normal parathyroid glands using MB and Chapter 8 described the intraoperative identi cation of ovarian cancer metastases using enhanced permeability and retention of ICG.
Chapter 9 reports the identi cation of ovarian cancer metastases and primary breast cancer using the tumor-speci c folate receptor alpha (FRα) targeting agent EC17. Chapter 10 describes the successful clinical translation of a new tumor-speci c contrast agent in the near-infrared spectrum targeting the FRα in healthy subjects and patients.
In Chapter 11, all results are summarized and the future perspectives are discussed.
General introduction and thesis outline 15