Page 24 - Sentinel lymph node biopsy in oral cavity cancer - Inne J. den Toom

Chapter 1 Chapter 7 illustrates the additional value of the SPECT-CT as imaging modality for identification of SLNs. We compare planar lymphoscintigraphy to SPECT-CT by scoring the number of SLNs, the pathology of SLNs and investigate if the SPECT-CT provides additional important anatomical information about the localisation of SLNs pre-operatively. To reliably compare a new radioactive agent for SLN identification ([99mTc]Tc- tilmanocept), we conducted a head to head comparative prospective study in which 20 patients received the routinely used tracer ([99mTc]Tc-nanocolloid) as well as the new tracer ([99mTc]Tc-tilmanocept). The results of this non-inferiority study are described in chapter 8. 22