Page 148 - Sentinel lymph node biopsy in oral cavity cancer - Inne J. den Toom

Chapter 8 120 MBq) lymphoscintigraphy. After the first cohort, interim analysis was carried out before continuing with the second cohort. In cohort 2, tracers were administered in opposite order; first 74 MBq [99mTc]Tc- nanocolloid, followed by 74 MBq [99mTc]Tc-tilmanocept. In both cohorts the same imaging protocol was applied. In an effort to administer both tracers at the same injection spots, photographic images were made of the peritumoural injections with consent of patients. Following injection of the second radio-agent, the same imaging protocol was applied. Patients reported their pain scores during the injection procedure for both tracers using the Numeric Pain Rating Scale (NPRS).15 Figure 3. Study design Abbreviations; [99mTc]Tc-tilm., [99mTc]Tc-tilmanocept; [99mTc]Tc-nano., [99mTc]Tc- nanocolloid; LSG, lymphoscintigraphy 146