Page 133 - Cellular Imaging in Regenerative Medicine, Cancer and Osteoarthritis
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Albutate-1, a novel long-circulating radiotracer
gradually decreased down to 2.51 ± 0.22%ID/g at 168 h with a Tclr of 27.5 ± 2.6 h. (Figure 5). The measured tumor uptake was 7.07 ± 1.87%ID/g at 1 h p.i.. At 24 h p.i. the tumor uptake was 24.42 ± 1.44%ID/g and reaching 8.82 ± 1.92%ID/g at 168 h p.i. (Figure 6).
Figure 5 Blood residence of [177Lu]Lu-Albutate-1 as a function of time (n=4). The Albutate-1 data was fitted (R2=0.98) with a one phase decay curve with Tclr = 27.5 ± 2.6 h. The error bars indicate 1 standard deviation and the shaded regions indicate the 95% confidence interval.
Figure 6 Tumor uptake of [177Lu]Lu-Albutate-1 as a function of time (n = 4). The Albutate-1 data was fitted (R2=0.87) with a bi-exponential curve with Tupt = 2.52 ± 0.98 h and Tclr = 80 ± 19 h. Error bars indicate 1 standard deviation and 95% confidence interval of the fits are indicated.
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