Page 121 - Cellular Imaging in Regenerative Medicine, Cancer and Osteoarthritis

Stabilized Sarabesin-3 for prostate imaging
Conclusions
Co-administration of [111In]SB3 with the NEP inhibitor PA, led to a significant increase of in vivo stability of [111In]SB3. So, SPECT/MRI using [111In]SB3 + PA resulted in excellent visualization of tumors in our preclinical model, indicating its potency for (pre-operative) imaging and future radio-guided surgery applications.
Acknowledgments
All imaging experiments were conducted at the Applied Molecular Imaging ErasmusMC (AMIE, http://www.erasmusmc.nl/amie/). The authors thank Rory de Zanger and Ho Sze Chan for their technical assistance.
Disclosures
The authors declare that they have no conflict of interest. All applicable institutional and/or national guidelines for the care and use of animals were followed.
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