Page 81 - Assessing right ventricular function and the pulmonary circulation in pulmonary hypertension Onno Anthonius Spruijt

[16]. SDs of the bias of the interobserver variability of the different echo parameters were used as a cut-off value to define an echo-based deterioration in RV function. Statistical analyses were performed using SPSS version 20 for Windows (IBM Corp. Armonk, NY, USA), GraphPad Prism version 6.0 (Graphpad Software, Inc. San Diego, CA, USA) and Stata version 12 (Stata Corp. Stata Statistical Software: release 12. College Station, TX, USA). A p-value < 0.05 was considered statistically significant.
Results
Clinical, hemodynamic and cardiac characteristics are summarized in table 1 and 2.
Clinical characteristics
Age (yr)
Sex (M:F) (n)
BMI
BSA
NYHA functional class I/II/III/IV (n) 6MWD (m)
Pro-BNP (ng/L)
Diagnosis (n)
Pulmonary arterial hypertension (PAH) (WHO group I) Idiopathic/heritable PAH
Associated with connective tissue disease Associated with congenital heart disease Pulmonary veno-occlusive disease
CTEPH (WHO group IV)
PH with unclear and/or multifactorial mechanism (WHO group V)
Treatment (n)
Treatment naive Monotherapy (ERA or PDE5I) Calcium channel blockers Dual combination therapy ERA+PDE5I
ERA + prostacyclin
PDE5I + prostacyclin
53 ± 16 27 : 69 25 ± 4.6 1.83 ± 0.2 10/56/22/8 412 ± 147 1730 ± 2824
75 54 13 7 1 17 4
31 18 2 35 26 3 6
Chapter 5
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