Page 55 - Assessing right ventricular function and the pulmonary circulation in pulmonary hypertension Onno Anthonius Spruijt

correlates of outcome included right ventricular ejection fraction (RVEF) (chi-square=12; p<0.001), RA index (chi-square=11; p<0.001), RV end-systolic volume index (chi-square=9; p<0.001), right heart score (chi-square=14; p<0.001), and more weakly 6MWD (chi-square=5; p=0.03). On multivariable analysis, right heart score (HR: 1.9 per grade; 95%CI: 1.4-2.6) and age (HR: 1.3 per grade; 95%CI: 0.98-1.69) were the only 2 variables independently associated with outcome, with chi- square=19 (p<0.001).
Figure 5: Right Heart Score in Relation to the REVEAL and NIH Scores. A: Five-year Kaplan-Meier curve on the basis of the right heart score. B: C-statistic between the right heart score and the REVEAL (Registry to Evaluate Early and Long-Term PAH Disease Management) score and 5-year predicted National Institutes of Health (NIH) survival. C: Strong relationship between the right heart score and the REVEAL score, with 95% CI for the mean value. (D) Strong relationship between the right heart score and the NIH score, with 95% confidence interval for the mean value.
The c-statistic for the right heart score in the validation cohort (0.76; IQR: 0.66-0.84) was significantly different from the c-statistic for the NIH survival equation (0.59; IQR: 0.48-0.70;
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