Page 49 - Assessing right ventricular function and the pulmonary circulation in pulmonary hypertension Onno Anthonius Spruijt

pulmonary vascular resistance index (PVRI) score was 25±12 WUxm2. Forty-five percent of patients (n=43) were on prostanoid therapy, and 19% of patients (n=18) were on combination therapy. Figure 3 summarizes the relationship between RA size, RAEF, and RV function as assessed by RVFAC. Compared with healthy controls, patients with PAH had a greater degree of RA and RV enlargement and lower RAEF. In general, RA enlargement and impaired active RAEF were more common among patients with severe RV dysfunction (Figures 3B and 3D).
Figure 3: Ventricular and Atrial Remodeling and Function in the Study Population. A: Box-and-whisker plot of indexed RA and RV areas of patients with pulmonary arterial hypertension (PAH) and healthy controls. B: Box-and-whisker plot of indexed RA area according to the pre-defined categories of right ventricular dysfunction (RVD). C: Box-and-whisker plot of total, active, and passive RAEF of patients with PAH and healthy controls. D: Bar graph with 95% confidence interval for mean value for active RAEF, stratified according to the pre-defined categories of RA size. In the box-and-whisker plots, the central box represents the values from the lower to upper quartile (25th to 75th percentile); the middle line represents the median; and the line extends from the minimum to the maximum value, excluding outlier values. RAE = right atrial enlargement; RVF = right ventricular function; other abbreviations as in Figures 1 and 2.
Chapter 3
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