Page 133 - Assessing right ventricular function and the pulmonary circulation in pulmonary hypertension Onno Anthonius Spruijt

CMR scans were performed on a Siemens 1.5T Sonato or Avanto scanner (Siemens Medical Solutions, Erlangen, Germany). Acquisition and post‐processing were performed as described previously [25].
Chapter 8
Age (yr)
Sex (M:F) (n)
NYHA functional class I/II/III/IV (n) 6MWD (m)
NT‐ProBNP
Treatment
Treatment naive
Monotherapy (ERA or PDE5I)
Dual combination therapy (ERA+PDE5I)
Triple combination therapy (ERA + PDE5I + prostacyclin) Hemodynamic characteristics
Heart rate (beats/min)
Mean pulmonary artery pressure (mmHg) Pulmonary arterial wedge pressure (mmHg) Mean right atrial pressure (mmHg) Pulmonary vascular resistance (dyn.s/cm5) Cardiac output (l/min)
Mixed venous O2 saturation (%)
Cardiac magnetic resonance imaging RVEDVI (ml/m2)
RVESVI (ml/m2)
RVEF (%)
IPAH (n=8)
46 ± 12 4 : 4
518 ± 125 641 ± 992
1 1 3 3
79 ± 8 52±20 8±3 7±4
686 ± 482 5.6 ± 1.7 68±10
93±21 59±23 39±11 63 ± 8
Controls (n=6)
68 ± 9 3 : 3
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‐
‐
‐ ‐ ‐ ‐
‐ ‐ ‐ ‐ ‐ ‐ ‐
LVEF (%)
Table 1: Clinical Characterization of Patients with Idiopathic Pulmonary Arterial Hypertension (IPAH) and 6 controls with unilateral lung cancer. M = males; F = females; NYHA = New York Heart Association functional class; 6MWD = six minute walk distance; ERA = Endothelin Receptor Antagonists; PDE5I = Phosphodiesterase‐5 Inhibitors. RVEDI = right ventricular end diastolic volume index; RVESV = right ventricular end systolic volume index; RVEF = right ventricular ejection fraction; LVEF = left ventricular ejection fraction.
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