Page 175 - Risk quantification and modification in older patients with colorectal cancer

Appendix A Baseline characteristics of responders and non-responders (T0)
Responders Non-responders
Oncogeriatric care and Health Related Quality of Life
n=106
n=32
p-value (6) 0.046
0.8
(56) (44)
(24) 0.7 0.06
Mean Age (SD) 76.4 Gender (%)
Male 57
Female 49 Functionally Dependent
Barthel Index < 19 or Katz ADL ≥ 2a 26 Tumour location
Colon 71
Rectum 35 Tumour stage AJCCb
Stage I-II 64 Stage III 38 Stage IV 4
Neoadjuvant or adjuvant therapy
Chemoradiation/ 23 radiotherapy
Adjuvant chemotherapy 15
(4)
(54) (46)
(25)
(67) (33)
(60) (36) (4)
(22)
(14)
78.7
18 14
7
27 5
13 12 2
2 3
(84) (16)
(41) (38) (6)
0.4
(6) 0.047 (9) 0.5
aInformation based on 106 responders and 29 non-responders bInformation on tumour stage of 5 patients was missing
Appendix B Baseline characteristics of the study cohort and all patients from the participating centres from the same period (2014-2015)
Study cohort
n=106
All patientsa 2014-2015 n=923
77.8 (5) 0.04 0.08
Independent n=80
76.3 (4.0)
48 (60) 32 (40)
53 (66) 27 (34)
49 (61) 28 (35) 3 (4)
18 (23)
11 (14)
18 (23)
Dependent n=26
77.0 (4.0)
9 (35) 17 (65)
18 (69) 8 (31)
15 (58) 10 (38) 1 (4)
5 (19)
4 (15) 10 (38)
p-valueb
Mean age (SD) Gender
Male
Female
Tumour location Colon
Rectum
Tumour stage AJCC
Stage I-II
Stage III
Stage IV
Neoadjuvant or adjuvant therapy
Neo-adjuvant chemoradiation/radiotherapy
Adjuvant chemotherapy
Ostomy
496 (54) 427 (46)
738 (80) 185 (20)
527 (57) 301 (33) 95 (10)
0.01 0.3
aAll surgically treated patients for colorectal cancer (≥70 years) in the participating centres between 2014- 2015. Data from the Dutch Cancer Registry (NKR). b Between the three groups. Frequencies are shown with percentage (%) or mean with SD
107 (12) 0.02
149 (16) 0.9
245 (27) 0.3
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