Page 16 - Risk quantification and modification in older patients with colorectal cancer

Chapter 1
interventions are studied designed to modify the risk for poor surgical outcomes in older patients with CRC and quality of life and functional performance after CRC treatment, outcomes that are especially relevant to older patients, are studied (Part II).
Part I. risk quantification
In Chapter 2, a systematic review method is used to discuss existing prediction models and risk groups for adverse outcomes of colorectal surgery. Also, the different predictors and outcomes of these models are evaluated for their applicability to older patients.
In Chapter 3, the predictive value of the G8 and ISAR-HP screening tools are studied with regard to postoperative complications and 1-year mortality after colorectal cancer surgery in older patients. In Chapter 4, skeletal muscle mass and density are studied for their prognostic value for adverse events after CRC surgery. A comprehensive multicentre database containing demographic and geriatric data of 550 consecutive older patients provided the data for Chapter 5. In this chapter, we investigated the prognostic value of geriatric predictors based on the data of Chapters 2 to 5, a new preoperative prediction model for severe complications is presented in Chapter 6.
Part II. risk modification
In Chapter 7, the effect of a prehabilitation and rehabilitation program for older patients on 1-year mortality and complications, is studied. In Chapter 8, Health- Related Quality of Life (HRQoL) in the first postoperative year is investigated in older patients with colorectal cancer treated in a geriatric care pathway. Differences between patients with and without geriatric deficits are studied. Chapter 9 describes the effect of CGA on treatment decisions for older patients with colorectal cancer. Following a summary in Chapter 10, the main findings and future perspectives are discussed in Chapter 11.
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