Page 159 - Risk quantification and modification in older patients with colorectal cancer

Oncogeriatric care and Health Related Quality of Life
HRQoL was also completed at 3 (T3), 6 (T6), and 12 (T12) months after surgery. No ADL questionnaires were sent to patients at 6 months. Patients that did not complete a previous set of questionnaires were not invited for the sequential set. Patients that did not complete at least one set of questionnaires after T0 were excluded from the analysis.
Tumour and surgery-specific data were retrieved from the Netherlands Cancer Registry (NCR). This registry supplied demographic information including tumour characteristics (tumour stage and tumour location), surgical (open or laparoscopic surgery, whether or not with an ostomy) and medical treatment including neo- and adjuvant treatment.
From the NCR, we also retrieved demographic data of all non-participants (≥70 years) with surgical treatment in the same study period (2014-2015) from the participating study centres.
Health-related quality of life
HRQoL was assessed with the Dutch version of the validated European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) Core-30 (C-30) and EORTC QLQ-Colorectal-38 (CR-38).
The cancer-specific EORTC QLQ-C30 consists of 30 items belonging to five functional scales (physical functioning, role functioning, emotional functioning, cognitive functioning, social functioning), three symptom scales (fatigue, pain and nausea and vomiting), six single-item scales (dyspnoea, insomnia, appetite loss, constipation, diarrhoea and financial difficulties) and a global health item.26
A summary score of the QLQ-C30 was calculated that averages all functioning and symptom scores except financial problems and the global health scale and has been shown to have equal or even superior responsiveness to the underlying QLQ-C30 scale scores.27
The EORTC QLQ-CR38 consists of four functional scales (body image, sexual functioning and enjoyment, and future perspective), and eight symptoms scales (gastrointestinal and micturition problems, chemotherapy side effects, defecation problems, ostomy-related problems, weight loss, and male and female sexual problems).28
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