Page 30 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek

Chapter 2
Abstract
We aimed to compare HLA-DQB1-associations in narcolepsy type 1 patients with disease onset before and after the 2009 H1N1 pandemic in a large Dutch cohort. 525 narcolepsy type 1 patients and 1272 HLA- DQB1*06:02-positive healthy controls were included, because of the discussion that has arisen on the existence of sporadic and post-H1N1 narcolepsy type 1. HLA-DQB1-associations in pre- and post-H1N1 narcolepsy type 1 patients were compared. The associations between HLA-DQB1 alleles and narcolepsy type 1 were not significantly different between pre- and post-H1N1 narcolepsy type 1 patients. Both HLA-DQB1-associations with pre- and -post H1N1 narcolepsy type 1 reported in recent smaller studies were replicated. Our findings combine the results of studies in pre- and post-H1N1 narcolepsy type 1 and argue against considering post-H1N1 narcolepsy type 1 as a different entity.
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