Page 105 - The autoimmune hypothesis of narcolepsy and its unexplored clinical features M.S. Schinkelshoek

Direct transition from wake to REM sleep or from wake via N1 to REM sleep is not a highly sensitive measure for NT1 and NT2
People with NT1 and NT2 transited from wake to REM sleep and from N1 to REM sleep significantly more often than those with IH, OSA or ISS when all naps were taken into account (p < 0.001 for both sleep stage sequences; Figure 6.2A). However, when only naps with a SOREMP were analysed, transitions from wake to REM sleep and from N1 to REM sleep were not found more often in NT1 and NT2 than in IH, OSA and ISS (p > 0.05 for both sleep stage sequences; Figure 6.2B).
Figure 6.2. Sleep stage sequences in MSLT nap opportunities. A. Sleep stage sequences in all nap opportunities. Wake to REM and wake via N1 to REM sequences are represented for NT1, NT2, IH, OSA and ISS patients as a percentage of the total nap opportunities for that diagnosis. Statistical significance of differences between NT1, NT2 and IH, OSA and ISS patients is shown by the horizontal bars. B. Sleep stage sequences in nap opportunities with a SOREMP. Wake to REM and wake via N1 to REM sequences are represented for NT1, NT2, IH, OSA and ISS patients as a percentage of the nap opportunities with a SOREMP for that diagnosis.
*** p<0.001; ns p>0.05; IH = idiopathic hypersomnia; ISS = insufficient sleep syndrome; NT1 = narcolepsy type 1; NT2 = narcolepsy type 2; OSA = obstructive sleep apnea; W = wake.
Daytime sleep state misperception
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