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Table of Contents
Chapter 1
General introduction & outline of the thesis;
mTOR dysregulation and tuberous sclerosis related epilepsy
7
Chapter 2
Novel histopathological patterns in cortical tubers of epilepsy surgery patients with tuberous sclerosis complex
27
Chapter 3
Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: implications for pathophysiology and treatment
47
Chapter 4
Dysregulation of the (immuno)proteasome pathway in malformations of cortical development
79
Chapter 5
Expression of microRNAs miR21, miR146a, and miR155 in tuberous sclerosis complex cortical tubers and their regulation in human astrocytes and SEGA-derived cell cultures
111
Chapter 6
miR147b: a novel key regulator of interleukin 1 beta-mediated inflammation in human astrocytes
143
Chapter 7
Discussion
173
Chapter 8
Summary
189
Chapter 9
Nederlandse samenvatting
195
Chapter 10
List of publications
201
Chapter 11
Portfolio
207
Chapter 12
Curriculum Vitae
213
Chapter 13
Dankwoord
217
