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Three
Coding and small non-coding
transcriptional landscape of tuberous
sclerosis complex cortical tubers:
implications for pathophysiology and
treatment
James D. Mills1a,†, Anand M. Iyer1a,†, Jackelien van Scheppingen1a, Anika Bongaarts1a, Jasper J. Anink1a, Bart Janssen2, Till S. Zimmer1a, Wim G. Spliet3a, Peter C. van Rijen3b,d, Floor E. Jansen3,d, Martha Feucht4a, Johannes A. Hainfellner4b, Pavel Krsek5a, Josef Zamecnik5b, Katarzyna Kotulska6, Sergiusz Jozwiak6, Anna Jansen7, Lieven Lagae8, Paolo Curatolo9, David J. Kwiatkowski10, R. Jeroen Pasterkamp3d , Ketharini Senthilkumar3d, Lars von Oerthel11, Marco F. Hoekman11, Jan A. Gorter11 Peter B. Crino12, Angelika Mühlebner1a, Brendon P. Scicluna1b,c,*, Eleonora Aronica1a,11,13,*
1Department of (Neuro)Pathologya,Center for Experimental & Molecular Medicineb and Department of Clinical Epidemiology, Biostatistics and Bioinformaticsc, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands, 2GenomeScan BV, Leiden, the Netherlands, 3Departments of Pathologya and Neurosurgeryb, Pediatric Neurologyc and Translational Neuroscienced, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands, 4Department of Pediatricsa and Institute of Neurologyb, Medical University Vienna, Austria, 5Department of Pediatric Neurologya and Department of Pathology and Molecular Medicineb, Charles University, Second Medical School, Motol University Hospital, Prague, Czech Republic, 6Department of Neurology and Epileptology, The Children’s Memorial Health Institute, and Department of Child Neurology, Warsaw Medical University, Warsaw, Poland, 7Pediatric Neurology Unit - UZ Brussel, Brussels, Belgium, 8Department of Development and Regeneration-Section Pediatric Neurology, University Hospitals KU Leuven, Leuven, Belgium, 9Systems Medicine Department, Child Neurology and Psychiatry Unit, Tor Vergata University Hospital of Rome, Italy, 10Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA, 11Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, The Netherlands, 12Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA, 13Stichting Epilepsie Instellingen Nederland (SEIN), The Netherlands, † Authors contributed equally to the present work, * These authors share the senior authorship
Plos Sci Rep. 2017; 7(1):8089