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NOVEL HISTOPATHOLOGICAL PATTERNS IN CORTICAL TUBERS IN TSC
We can only speculate about the significance of such findings to help identify the epilep- togenic zone, but they might give insights into the high similarity of TSC cortical tubers and resected FCD type IIB lesions with regard to their epileptogenicity 38. It is clear that neuroimaging findings are increasingly relevant in relation to identifying the epilepto- genic zone 38, 39, 24.
In summary, we have identified three distinct histological patterns in TSC corti- cal tubers based on quantitative histological features to increase our understanding of the differences among these lesions, and to lay the groundwork for further research on the functional and molecular effects of the different tuber types.
Acknowledgments
The authors thank all supporters of the TSC brain bank (the Service d’ Anatomie Pathologique, CHI de Creteil and Inserm U676, Hospital Robert Debre, Paris, France: H. Adle-Biassette; Department of Neuropathology, John Radcliffe Hospital, Oxford, UK: C. Kennard; Department of Anatomic Pathology Sciences, Università Sapienza, Rome, Italy: M. M. Antonelli, F. Giangaspero; Evangelisches Krankenhaus Mara Bethel- Bielefeld, Bielefeld, Germany: C. G. Bien, T. Polster, V. Hans; Insitute of Neuropathology, Westfälische Wilhelms – Universität Münster, Münster, Germany: W. Paulus; Department of Neuropathology, University Hospital Erlangen, Erlangen, Germany: R. Coras, I. Blümcke; Department of Neuropathology, Centro Hospitalar Lisboa Norte, EPE, Lisbon, Portugal: J. Pimentel; Department of Pathology, Hacettepe University Medical Faculty, Ankara, Turkey: F. Söylemezoğlu; Department of Human Pathology and Oncology, University of Florence and Division of Neurosurgery, ‘Anna Meyer’ Pediatric Hospital, Florence, Italy: A. M. Buccoliero, F. Giordano. Department of Neuropathology, John Radcliffe Hospital, Oxford, UK: W. Squier.
Additionally, we thank the personnel of the Epilepsy Monitoring Units of the Centers in Utrecht, Vienna and Prague for patient care as well as the corresponding pathology laboratories for processing the tissue samples. In this regard we would like to acknowledge all personnel involved in sending us the material. We would also like to thank O. de Boer for technical assistance and D. J. Kwiatkowski for his comments on the manuscript.
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