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MIR147B: A NOVEL KEY REGULATOR OF IL-1β-MEDIATED INFLAMMATION IN ASTROCYTES Inhibitor of astrocytic
Inhibitor of inflammation
Increased in astrocytes in human epileptogenic brain
Figure 7. Summary of the current findings.
Conclusion
miR147b miR146a
Promotes neuronal differentiation of NSCs
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Taken together, using small RNA-sequencing, we found miR147b and miR146a as main miRNAs involved in IL-1β-associated inflammation in fetal human astrocyte cultures and both are up-regulated under inflammatory conditions in astrocyte cultures, as well as in the human epileptogenic brain (Fig 7). Since miR147b is capable of providing negative feedback on inflammatory signaling and reducing aberrant proliferation and generation of astrocytes, miR147b deserves further investigation as potential therapeutic agent in neurological disorders associated with inflammation, such as TLE-HS and TSC.
Acknowledgements
The research leading to these results has received funding from the European Union’s Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 602391 (EPISTOP; J.v.S., E.A., F.E.J.) and no. 602102 (EPITARGET; E.A., E.A.v.V., A.V.), the Dutch Epilepsy Foundation, project number 13-01 (E.A., V.I., A.V.) and 16-05 (D.W.M.B., E.A.v.V.) and the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement no. 642881 (ECMED; A.K., E.A.) and no. 722053 (EU-GliaPhD; T.S.Z., E.A.). We acknowledge the HIS Mouse Facility of the Academic Medical Center, Amsterdam and the Bloemenhove Clinic (Heemstede, The Netherlands) for providing fetal tissues.
proliferation
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