Page 35 - The clinical aspects and management of chronic migraine Judith Anne Pijpers

a screening questionnaire that has been validated priorly.17 Firstly, if patients fulfilled the screening criteria, they received a web-based extended migraine questionnaire, based on the ICHD-III beta criteria.15;16 This questionnaire was previously validated by a semi-structured telephone interview in 1038 patients who had filled out the extended migraine questionnaire.15 The specificity of the questionnaire was 0.95. Participants without the needed internet skills could fill out the questionnaires on paper. Secondly, all applicable migraine patients were selected for a web-based questionnaire on symptoms of depression. Patients were enrolled in this study after completion of the depression questionnaire. The response rate to the depression questionnaire was 80%.
Healthy controls and patients with psychopathology were derived from the Netherlands Study of Depression and Anxiety (NESDA), which is an ongoing cohort study designed to investigate the long-term course and consequences of depressive and anxiety disorders. Participants were adults aged 18-65 recruited from community (19%), general practice (54%), and secondary mental health (27%) facilities. A total of 2981 participants, including persons with current or past depressive and/or anxiety disorders and healthy controls, were assessed at baseline between 2004 and 2007. Exclusion criteria for the NESDA study were inability to speak Dutch and a known clinical diagnosis of other psychiatric conditions, such as bipolar disorder, obsessive-compulsive disorder, severe addiction disorder, psychotic disorder or organic psychiatric disorder. A detailed description of the NESDA study design can be found elsewhere.18 In summary, the baseline assessment was comprised of a face-to-face interview, including a standardized diagnostic psychiatric interview, a medical assessment, computer tasks, written questionnaires, and biological measurement. For the current study, migraine patients, identified through a screening migraine questionnaire largely in accordance to the ICHD-III beta criteria for migraine (described in detail elsewhere)19, were excluded from the NESDA population.
The LUMINA project was approved by the medical ethics committee of the Leiden University Medical Centre. The NESDA research protocol was approved by the Ethical Committee of participating universities. All respondents provided written informed consent.
Measurements
In the NESDA study, the presence of psychiatric disorders was determined by using the Composite International Diagnostic Interview (CIDI, version 2.1).
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Affective disorders in migraine patients
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