Page 17 - The clinical aspects and management of chronic migraine Judith Anne Pijpers
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Figure 2. Central sensitisation and cutaneous allodynia
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General introduction
A: Sensitisation of trigeminal afferents, causing intracranial hypersensitivity
Activation and sensitisation of trigeminal afferents causes intracranial hypersensitivity
B: Sensitisation of the TNC, causing cephalic allodynia
Recurrent stimulation by trigeminal afferents induces sensitisation of the TNC, causing cutaneous allodynia in the referred sensory area (ipsilateral, cephalic allodynia)
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