Page 116 - The clinical aspects and management of chronic migraine Judith Anne Pijpers

Chapter 6
Figure 2. Odds ratio for reversion from chronic to episodic migraine of no allodynia compared to different subtypes of allodynia.
* p < 0.05; ** p < 0.01
Cutaneous allodynia and the subtypes based on spatial distribution and type of stimulus were also predictive for the migraine specific secondary outcome measures. Participants without allodynia had a more than 2 times higher odds on ≥50% response (defined as ≥50% reduction in monthly migraine days) (OR 2.28; 95%CI 1.01 to 5.16; p = 0.048, Supplementary Table 1). The absence of allodynia was also predictive for the absolute reduction in monthly migraine days (MMD), with a reduction of 9.4 versus 5.9 MMD in participants without allodynia versus participants with allodynia (difference 3.49, 95% CI 0.95 to 6.02, p = 0.007). Similar to the primary outcome, the predictive value was more pronounced when subdivided by spatial distribution, and mainly related to mechanical allodynia, not thermal allodynia (mean differences in Table 3). However, neither cutaneous allodynia in general, nor the subtypes of cutaneous allodynia were predictive for reduction in monthly headache days (MHD) (Table 3). All the associations on primary and secondary outcomes did not alter after adjusting for medication days and migraine (MMD) or headache days (MHD) at baseline in supplementary analyses (data not shown).
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