Page 126 - Human Bile Acid Metabolism: a Postprandial Perspective

Chapter 7
Abstract
Patients with type 2 diabetes (T2D) have a disturbed diurnal rhythm of plasma glucose tolerance. We hypothesized that this may be due to altered diurnal regulation of plasma bile acid (BA) levels. We provided six T2D patients and six age-matched healthy controls with three identical meals per day, and measured plasma concentrations of primary and secondary BAs using tandem mass spectrometry. Postprandial BA responses were not affected by time of day. However, postprandial peak times were earlier for total BAs, chenodeoxycholic acid, and glycine conjugates in T2D, which may be explained by increased intestinal and/or decreased liver BA uptake.
Keywords: Diurnal rhythm, obesity, type 2 diabetes, bile acids, glucose metabolism Funding details: D.J.S. was supported by ZonMW Agiko stipend 92003592. M.R.S was supported by the Dutch Diabetes Resarch Foundation [grant number 2011.80.1423]. The project was supported by Abbott Nutrition with a financial grant and in-kind contribution of Ensure Plus and FreeStyle Navigators. The sponsors were involved in study design only.
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