Page 80 - Advanced echocardiography in characterization and management of patients with secondary mitral regurgitation

Chapter four. Regurgitant Volume/Left Ventricular End-Diastolic Volume Ratio
is limited by various previously described assumptions (30), and CMR data were not systematically available. Furthermore, a significant proportion of patients were referred for intervention, which limits the power to demonstrate the association between RVol/ EDV and all-cause mortality while receiving medical therapy. Finally, the sample size limited our ability to examine which MV interventions were beneficial or hazardous according to RVol/EDV ratio.
Conclusions
In patients with significant secondary MR who were treated medically, survival tended to be lower in those with a higher RVol/EDV ratio. Conversely, a high RVol/EDV ratio was independently associated with reduced all-cause mortality if this group received therapies to correct the MR. By accounting for the relative severity of both MR and LV volume, the RVol/EDV ratio may further improve risk stratification of patients with secondary MR and identify those who may benefit from transcatheter and surgical therapies to reduce severe secondary MR.
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