Page 124 - Advanced echocardiography in characterization and management of patients with secondary mitral regurgitation

Chapter six. Right ventricular - pulmonary artery coupling
LV GLS was -7.3% [-9.9, -5.2]. The mean TAPSE was 16±5 mm and the mean PASP was 30±13 mmHg for the total population. During a median follow-up of 35 [17, 63] months, mitral valve intervention was performed in 258 (43.7%) patients, including 168 (28.4%) surgical mitral valve repairs, 2 (0.3%) surgical mitral valve replacements, and 88 (14.9%) transcatheter mitral valve repairs. Baseline clinical and echocardiographic characteristics are summarized in Tables 1 and 2.
Table 1. Baseline clinical characteristics according to TAPSE/PASP ratio.
Age (years)
Male, n (%)
BSA (m2)
Prior CABG
Atrial fibrillation, n (%) Hypertension, n (%) Diabetes mellitus, n (%) COPD, n (%)
eGFR (mL/min/1.73m2) Ischemic heart failure, n (%) NYHA class, n (%)
I II III IV
Medication, n (%) Beta-blockers
Diuretics ACEi/ARB
Device therapy, n (%) ICD
CRT*
Total population (n= 591)
66 ± 11 395 (67) 1.92 ± 0.21 101 (17) 248 (42) 240 (41) 138 (23) 68 (12)
62 ± 24 304 (51)
31 (5) 145 (25) 343 (58) 72 (12)
419 (71) 496 (84) 480 (81)
94 (16) 401 (68)
TAPSE/PASP ratio < 0.35 (n= 229)
68 ± 10 165 (72) 1.92 ± 0.21 53 (23) 120 (52) 98 (43)
57 (25) 29 (13) 58 ± 23 131 (57)
12 (5) 51 (22) 192 (56) 37 (16)
163 (71) 210 (92) 177 (77)
53 (15) 148 (65)
TAPSE/PASP ratio ≥ 0.35 (n= 362)
65 ± 11 230 (64) 1.93 ± 0.21 48 (13) 128 (35) 142 (39) 81 (22)
39 (11)
65 ± 24 173 (78)
19 (5) 94 (26) 214 (59) 35 (10)
256 (71) 286 (79) 303 (84)
41 (18) 253 (70)
p-value
0.008 0.032 0.773 0.002 <0.001 0.390 0.481 0.483 0.001 0.026 0.121†
0.904 <0.001 0.052
0.291 0.182
Continuous data are presented as mean ± SD or median [Q1, Q3]. Categorical data are presented as numbers and percentages. *CRT at baseline and follow-up. † overall P-value. ACE = angiotensin-converting enzyme; ARB = angiotensin receptor blocker; BSA = body surface area; COPD = chronic obstructive pulmonary disease; eGFR = estimated glomerular filtration rate; NYHA = New York Heart Association.
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