Page 55 - Physiological based CPAP for preterm infants at birth Tessa Martherus

Results
Comparison of two respiratory support strategies for stabilization of very preterm infants at birth
In total, 54 infants were included in this study. The University Hospital of Cologne and the
LUMC stored 87 and 527 recordings of neonatal resuscitations. Twelve infants could not be identified and 429 infants were excluded based on gestation. One hundred and twenty-five
infants were excluded due to congenital abnormalities, incomplete files or because they could
not be matched (Figure 1). The groups were similar in gestational age, birth weight, gender, application of steroids and tactile stimulation (yes or no) within the first 7 min after birth
(Table 1). Mode of delivery (low- vs. high-pressure group; % cesarean section; 44 vs. 100%,
p <0.001) and Apgar score ‘1 min after birth (5 (3-7) vs. 6 (5-7), p=0.048) were significantly
different between groups. Nine infants of the high-pressure group were delivered within the
amniotic sac, and for two infants it is unknown if they were delivered within the amniotic sac. 2
P
Table 1. Baseline characteristics Gestational age (weeks) a
Birth weight (grams) a Gender (% male) b Antenatal corticosteroids (% started) b
Antenatal corticosteroids
(% full dose) b
Mode of delivery
(% caesarean section) b
Tactile stimulation b
Apgar score at 1 minute after birth a
Low-pressure High-pressure group (n=27) group (n=27)
P-value
26+1 (24+6-27+3) 827 (660-975) 13 (48)
25 (93)
13 (52)* 12 (44)
17 (74)*
Wilcoxon Signed Rank Test (a) and Related-Samples McNemar test (b). * N<27.
5 (3-7)
Data are presented as median (IQR) and n (%), p-values are presented of Related-Samples
26+0 (24+5-27+2) 750 (650-960) 17 (63)
24 (89)
18 (78)*
27 (100)
15 (60)*
0.459 0.156 0.388 1.000
0.070
<0.001
0.508
6 (5-7)
0.026
51
r