Page 53 - New epidemiological and PSMA-expression based paradigms in salivary gland tumors
P. 53

􏰘􏰗􏰖$!􏰕 􏰓􏰒 􏰘􏰑􏰐% 􏰏􏰗􏰎􏰖!􏰎􏰍 􏰐􏰌 #􏰋􏰕 􏰊􏰐􏰍􏰉􏰗􏰈􏰕􏰏 􏰇􏰎􏰈􏰗"􏰋􏰆􏰇$#􏰊􏰋 􏰅􏰄􏰃 􏰂􏰁 􏰐 $􏰑􏰎#􏰗􏰐􏰈􏰀 %􏰗#􏰋 !􏰕􏰊$!!􏰕􏰈􏰊􏰕" 􏰎􏰈􏰏 􏰙􏰚􏰀 "􏰋􏰐%􏰗􏰈􏰖 􏰋􏰐% !􏰐 􏰐!#􏰗􏰐􏰈" 􏰎!􏰕 􏰊􏰎􏰑􏰊$􏰑􏰎#􏰕􏰏􏰛􏰜􏰀􏰓 􏰅􏰘􏰐! 􏰌􏰑􏰐% 􏰏􏰗􏰎􏰖!􏰎􏰍" 􏰐􏰌
"􏰕 􏰎!􏰎#􏰕 􏰇􏰎􏰈􏰗"􏰋 􏰎􏰈􏰏 􏰇$#􏰊􏰋 􏰐 $􏰑􏰎#􏰗􏰐􏰈"􏰀 "􏰕􏰕 􏰝$ 􏰑􏰕􏰍􏰕􏰈#􏰎􏰑 􏰌􏰗􏰖$!􏰕" 􏰁 􏰎􏰈􏰏 􏰞􏰛􏰃
Natural history of recurrent pleomorphic adenoma
  􏰃􏰓􏰚􏰙􏰏􏰘 􏰓􏰚􏰞 􏰃􏰌􏰕􏰁􏰘 -$$' 􏰆􏰅􏰑 􏰎􏰖􏰄􏰊􏰓􏰂􏰂 􏰝􏰄􏰓􏰚 􏰇􏰎􏰂􏰂􏰎􏰋􏰈􏰌􏰉 %&􏰍) 􏰗􏰄􏰓􏰊􏰏
    3
  &)- %􏰏􏰕 􏰛􏰆􏰅 1 &􏰍-0 􏰎􏰇 􏰆􏰅􏰏􏰑 -'􏰍,0 􏰎􏰇 􏰊􏰄􏰁􏰌􏰊􏰊􏰄􏰚􏰕 􏰕􏰌􏰝􏰎􏰊􏰏
%+ 􏰀􏰜 1 $􏰍&0 􏰎􏰇 􏰆􏰅􏰏􏰑 *􏰍&0 􏰎􏰇 􏰊􏰄􏰁􏰌􏰊􏰊􏰄􏰚􏰕 􏰕􏰌􏰝􏰎􏰊􏰏
􏰚􏰎 􏰊􏰄􏰁􏰌􏰊􏰊􏰄􏰚􏰁􏰄 􏰐􏰚1,+&+
       Figure 2: Flow diagram of the combined Danish-Dutch (C) PA population, with recurrences and MT, showing how proportions are calculated.1,2 (For flow diagrams of separate Danish and Dutch populations, see Supplemental figures A and B.)
Table 2: Clinical course of Dutch and Danish patients (A-F) with a malignant transformation (MT) after an earlier treated RPA (also see figure 2C).
Recurrences (n)
Case 1 2 3 4 5 6 7 8 9 Time to MT (months)
A 53128MT1283LR 85
B 56 MT114 170
C 48 13 5 18 6 6 11 11 MT35 153
D 6 12 50 32 34 25 56 60 MT49 324
E 25 24 6 12 17 183 27MT29 323
F 13 7 MT5 25
MT=malignant transformation; LR=local recurrence
* 􏰄􏰖􏰄􏰚􏰕􏰌􏰓􏰂􏰂􏰗 􏰀􏰜! 1 $􏰍$+0 􏰎􏰇 􏰆􏰅􏰏 *􏰍+0 􏰎􏰇 &􏰚􏰞 􏰊􏰄􏰁􏰌􏰊􏰊􏰄􏰚􏰕 􏰕􏰌􏰝􏰎􏰊􏰏 !􏰞􏰄􏰕􏰓􏰙􏰂􏰏 􏰊􏰄􏰉􏰎􏰊􏰕􏰄􏰞 􏰙􏰚 􏰜􏰓􏰒􏰂􏰄 &
􏰚􏰎 &􏰚􏰞 􏰊􏰄􏰁􏰌􏰊􏰊􏰄􏰚􏰁􏰄 􏰐􏰚1%*-
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    51
 􏰑􏰘􏰜 􏰀􏰓􏰛􏰉􏰝􏰝􏰓􏰘􏰎 􏰎􏰉􏰇􏰙􏰝 􏰕􏰘$ 􏰋􏰌 􏰗􏰚􏰎 􏰀􏰓􏰛􏰉􏰝􏰝􏰓􏰘􏰎 􏰎􏰉􏰇􏰙􏰝 􏰃􏰝􏰞􏰇􏰆􏰝􏰊
$􏰍􏰍# 􏰙􏰒 􏰗􏰚􏰎 􏰀􏰃􏰅􏰚 􏰕􏰘$􏰑􏰐􏰈􏰌 $􏰍􏰏􏰗# 􏰙􏰒 􏰃􏰅􏰚 􏰃􏰄􏰓􏰙􏰇􏰙􏰝􏰂􏰁􏰞􏰛 􏰆􏰜􏰓􏰘􏰙􏰇􏰆










































































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