Page 41 - New epidemiological and PSMA-expression based paradigms in salivary gland tumors

Salivary gland pleomorphic adenoma in the Netherlands
Third, since we retrieved all our information from non-standardized pathology reports, there may be an interpretation bias concerning the description of margins by pathologists and the information supplied by surgeons.
Conclusions
Nationwide pathology data regarding SGPA in the Netherlands in the period 1992-2012 reflect some remarkable incidence trends: female incidence was on the rise, there was a bimodal age distribution in women, and women were affected more often than men. These findings may suggest some underlying hormonal mechanism.
Overall figures for this period showed an ESR ranging between 4.2 and 4.9 per 100 000 person-years, a 4.6% first-recurrence rate after at least five years of follow- up, and a 6.7% recurrence rate at 20 years of follow-up. Malignant transformation had occurred in 1.1% of primary, and 0.15% of secondary SGPAs at 5 years of follow-up (3.2% of all recurrences).
Risk factors for recurrence were positive or uncertain surgical margins, younger age at primary diagnosis, and primary tumor location, with lower odds for minor- gland primaries to recur, when compared to parotid SGPAs. Where margin data were missing, the odds of recurrence were higher, which emphasizes the need for improved, possibly standardized reporting in a joint effort by both surgeons and pathologists alike.
Appendix A: Supplemental material
Supplementary data associated with this article can be found, in the online version, at http://dx.doi.org/10.1016/j.oraloncology.2017.01.004
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