Page 76 - Personalised medicine of fluoropyrimidines using DPYD pharmacogenetics Carin Lunenburg

Chapter 4
Supplementary Material
Search terms used to perform the literature review of DPYD-[5-FU/capecitabine/tegafur] interactions.
Search strategy
Pubmed was used to search English, Dutch, German articles were accepted. Keywords were the drugs of interest (fluorouracil, capecitabine and tegafur/S1), the gene and variations (DPYD, DPD, dihydropyrimidine dehydrogenase), and others (e.g. metabolizer, pharmacogenetics, polymorphism). The complete search string was;
Fluorouracil and capecitabine
Search performed in 2009: (“Fluorouracil”[Mesh] OR fluorouracil) AND (“Dihydropyrimidine Dehydrogenase Deficiency”[Mesh] OR metabolizer OR metaboliser OR polymorph* OR “Polymorphism, Genetic”[MeSH] OR “Pharmacogenetics”[MeSH]) AND (English[lang] OR German[lang] OR Dutch[lang])
(“capecitabine “[Substance Name] OR capecitabine) AND (“Dihydropyrimidine Dehydrogenase Deficiency”[Mesh] OR metabolizer OR metaboliser OR polymorph* OR “Polymorphism, Genetic”[MeSH] OR “Pharmacogenetics”[MeSH]) AND (English[lang] OR German[lang] OR Dutch[lang])
(“Fluorouracil”[Mesh] OR fluorouracil OR “capecitabine “[Substance Name] OR capecitabine) AND ((“Dihydrouracil Dehydrogenase (NADP)”[Mesh] OR (dihydropyrimidine dehydrogenase)) AND mutation) AND (English[lang] OR German[lang] OR Dutch[lang])
Search performed in 2014: (“Fluorouracil”[Mesh] OR fluorouracil OR “capecitabine” [Supplementary Concept] OR capecitabine) AND (“Dihydropyrimidine Dehydrogenase Deficiency”[Mesh] OR “Dihydropyrimidine Dehydrogenase Deficiency” OR metabolizer OR metaboliser OR polymorph* OR “Polymorphism, Genetic”[MeSH] OR “Pharmacogenetics”[MeSH]) AND (English[lang] OR German[lang] OR Dutch[lang])
Search performed in 2017: (“Fluorouracil”[Mesh] OR fluorouracil OR “Capecitabine”[Mesh] OR capecitabine OR fluoropyrimidines) AND (“Dihydrouracil Dehydrogenase (NADP)”[Mesh] OR “Dihydropyrimidine Dehydrogenase Deficiency”[Mesh] OR “Dihydropyrimidine Dehydrogenase Deficiency” OR “Dihydropyrimidine Dehydrogenase” OR DPYD OR DPD) AND (English[lang] OR German[lang] OR Dutch[lang])
Tegafur
Search performed in 2009 and 2012: (“Tegafur”[Mesh] OR tegafur[Text Word]) AND (“Dihydropyrimidine Dehydrogenase Deficiency”[Mesh] OR metabolizer OR metaboliser OR polymorph* OR “Polymorphism, Genetic”[MeSH] OR “Pharmacogenetics”[MeSH]) AND (English[lang] OR German[lang] OR Dutch[lang])
Search performed in 2015: (“Tegafur”[Mesh] OR “S 1 (combination)” [Supplementary Concept] OR “tegafur-gimeracil-oteracil” [Supplementary Concept] OR tegafur[Text Word] OR S1 OR S-1 OR Teysuno) AND (“Dihydropyrimidine Dehydrogenase Deficiency”[Mesh] OR Dihydropyrimidine Dehydrogenase OR DPD OR DPYD) AND (English[lang] OR German[lang] OR Dutch[lang])
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