Page 211 - Personalised medicine of fluoropyrimidines using DPYD pharmacogenetics Carin Lunenburg

Supplementary table 2. Toxicity of patients from three original databases and of the combined database (total)
Supplement
Type of event
Grade 2 Diarrhoea Grade ≥3 Diarrhoea
Grade 2 Mucositis Grade ≥3 Mucositis
Grade 2 Nausea Grade ≥3 Nausea
Grade 2 Vomiting Grade ≥3 Vomiting
Grade 2 Neutropenia Grade ≥3 Neutropenia
Grade 2 Leukocytopenia Grade ≥3 Leukocytopenia
Grade 2 Thrombocytopenia Grade ≥3 Thrombocytopenia
Grade 2 Anaemia Grade ≥3 Anaemia
Grade 2 Radiation dermatitis Grade ≥3 Radiation dermatitis
Grade 2 HFS Grade 3 HFS
Grade 2 Cardio toxicity Grade ≥3 Cardio toxicity
Grade 2 Fatigue Grade ≥3 Fatigue
Grade 2 Other toxicityc Grade ≥3 Other toxicityc
Grouped type of events
Grade 2 GI toxicityd Grade ≥3 GI toxicityd
Grade 2 HEM toxicitye Grade ≥3 HEM toxicitye
Grade 2 Overall toxicityf Grade ≥3 Overall toxicityf
DB#1:NKI (N=495) N (%)
56 (11.3) 43 (8.7)
15 (3) 3 (0.6)
ND ND
ND ND
5 (1) 10 (2)
27 (5.5) 10 (2)
3 (0.6) 2 (0.4)
ND ND
ND ND
12 (2.4) 4 (0.8)
10 (2) 5 (1)
ND ND
ND ND
67 (13.5) 44 (8.9)
29 (5.9) 12 (2.4)
93 (18.8) 61 (12.3)
DB#2:LUMC (N=239)
N (%)
50 (20.9) 19 (7.9)
5 (2.1) 4 (1.7)
14 (5.9) 3 (1.3)
15 (6.3) 2 (0.8)
5 (2.1) 5 (2.1)
24 (10) 7 (2.9)
3 (1.3) 3 (1.3)
26 (10.9) 2 (0.8)
80 (33.5) 9 (3.8)
7 (2.9) 1 (0.4)
7 (2.9) 1 (0.4)
33 (13.8) 4 (1.7)
13 (5.4) 7 (2.9)
56 (23.4) 22 (9.2)
24 (10) 10 (4.2)
118 (49.4) 38 (15.9)
DB#3:CRO (N=93)
N (%)
24 (25.8) 4 (4.3)
1 (1.1) -
2 (2.2) -
ND ND
-
1 (1.1)
18 (19.4) 6 (6.5)
1 (1.1) -
2 (2.2) -
3 (3.2) 4 (4.3)
1 (1.1) -
4 (4.3) 5 (5.4)
ND ND
38 (40.9) 6 (6.5)
26 (28) 4 (4.3)
18 (19.4) 6 (6.5)
55 (59.1) 19 (20.4)
TOTAL (N=827) N (%)
130 (15.7) 66 (8)
21 (2.5) 7 (0.8)
16 (4.8)a 3 (0.9)a
15 (6.3)b 2 (0.8)b
10 (1.2)
16 (1.9) 7
69 (8.3) 23 (2.8)
7 (0.8) 5 (0.6)
28 (8.4)a 2 (0.6)a
83 (25)a 13 (3.9)a
20 (2.4) 5 (0.6)
21 (2.5) 11 (1.3)
33 (13.8)b 4 (1.7)b
51 (15.4)a 13 (3.9)a
149 (18) 70 (8.5)
71 (8.6) 28 (3.4)
266 (32.2) 118 (14.3)
a Data of 332 patients;
b Data of 239 patients;
c Other toxicity includes anal pain, chronic enteritis, cystitis (genitourinary tract), dizziness, dysgeusia, enterocolitis, fever, headache, multi-organ failure, papulopustular rash, proctitis, radio-enteritis, skin hyperpigmentation, stomatitis, thromboembolic event, ulcer of the small intestine;
d GI toxicity includes diarrhoea, mucositis, nausea, vomiting;
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