Page 13 - Personalised medicine of fluoropyrimidines using DPYD pharmacogenetics Carin Lunenburg

General introduction
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Figure 1. Metabolic pathway of fluoropyrimidines
Abbreviations: CES: carboxylesterase; 5’dFCR: 5’-deoxy-5-fluorocytidine; CDA: cytidine deaminase; 5’dFUR: 5’-deoxy-5-fluorouridine; TP: thymidine phosphorylase; 5-FU: 5-fluorouracil; FUMP: fluorouridine monophosphate; FUDP: fluorouridine diphosphate; FUTP: fluorouridine triphosphate; RNA: ribonucleic acid; FUDR: fluorodeoxyuridine; FdUMP: fluorodeoxyuridine monophosphate; FdUDP: fluorodeoxyuridine diphosphate; FdUTP: fluorodeoxyuridine triphosphate; DNA: deoxyribonucleic acid; TS: thymidylate synthase; TYMS: gene encoding TS; dUMP: deoxyuridine monophosphate; dTMP: deoxythymidine monophosphate; DPD: dihydropyrimidine dehydrogenase; DPYD: gene encoding DPD; DHFU: 5,6-dihydrofluorouracil; FUPA: fluoro-ß-ureidopropionate; F-ß-AL: fluoro-ß-alanine.