Page 31 - 2019-06 presentatie LUMC

a t in th eN e th er d s, eg n an h , a n d - h y ven tuall y, 5 4.3% o ft he pre gnan tw om en s d r o x y - 2 - a l k e n a nce perceived as being ‘physiological’. By supervis s and postnatal periods in primary maternity ected) complications/pathology in secondary ma ernity care professionals’ expertise can be applied t o r n e α , β - u n sa e ndary care are defined in the List of Obstetric In at ie Lijs t )– a lis t b as ed on sc ien ti fi c ev id e n a n th e r isk s ele c tio n ,t he ind i ca tio n s fo r re fe on the structural similarity us maternity care professionals. Currently the t ished in 2003, is in use. Name 2-butenal crotonaldeh not only important during atal period. In the prenatal tboebeeffefcfteivcetivine dinetpercetvinegntaindg tions, promoting a healthy postnatal period professional alth of mother and child, to or physical and mental health ffect health and wellbeing. nting and the responsibilities the universal accessibility of in the Netherlands have ous ethnic origins are more a complete understanding of thesis is specifically focusing on primary m ementioned primary care midwives as the roximately 77% of the 2444 midwives in the Neth al tr(ans-ci erlands (83.2%) had their first maternity care ch care is provider e trans-2-hexe trans-2-octen trans-2-cis-6 newborns with complications or a secondary care. Thus these pr gatekeepers to secondary matern is that in the Netherlands, pregn essence perceived as being ‘phy births and postnatal periods in (expected) complications/patholo maternity care professionals’ exp guide the risk selection, the in secondary care are defined in t Indicatie Lijst) – a list based on various maternity care professio 2-propenal (acrolein) \[12\]. Between 1999 and 2012, the majority of ng. E 34.2% gave birth in a primary care setting \[13\]. ta rt ral follow-up visits in which diagnostic, counseli ities are performed. According to the standar nistartiaonosf -M2id-whivesx(KeNnOaV)l, the first prenatal visit e between the 6th and 8th week of pregnancy \[14\]. 6 prenatal visits should ideally be made, with an ave ssary medical care and the needs and expectatio without al bonds more ted bonds with or additional citral (mixtu neral and ger trans-2-trans ienal and postnatal care. Approximately 77% of the 2444 ondary a care \[12\]. Between 1999 and 2 mation on the organisation of Netherlands (83.2%) had their f se renatal and postnatal care by and 34.2% gave birth in a primary trans-2-octenal care system i i s furoa rt childbirth (natal care) and after bi Prenatal care encompasses sup confirmation during the prenatal several follow-up visits in which activities are performed. Accor Organisation of Midwives (KNOV) made between the 6th and 8th w to 16 prenatal visits should ideally necessary medical care and the er 1trans-2-cis-6-nonadie l by only ref nal stnatal pe ed to be e he Dutch maternity care sy t u r a a ild l t s ter ni ty c ar e e d a l d b irt h an d th Opmaak en vormgeving van uw proefschrift Vanuit PDF my.thesis nl • Basic; toevoeging 1 grafisch element, omzetten naar drukbestand F opmaak basic € sche uiting: General introduction rr ce category without jugated e bonds Nam carbald 2-propenal ( PDF design 75,- Vanuit Word doc • Standaard: toevoeging 3 grafische elementen, omzetten naar drukbestand ptekst, òf paginacijfers, òf zijkant blokje Binnen werk α,β-unsaturation in p-mentha-1,8(10)-die side chain n-9-al to α,β-unsaturated aldeh ein) and 2-butenal (cr p-ment anic materials and theref t from engines \[2, 10\]. 2-P al e \[2\]. α,β-Unsaturated ald olyunsaturated fatty acids reaction mechanism, yi ent decomposition of lipi 2-propenal, 4-hydroxy-2- 2,6,6-tr les of food-borne α,β-un al yEFSAbasedxonath-e1st,ru3c urated aldehydes also comes from other sources than the diet. Alicyclic dere grafische uitingen tegen meerprijs butenal (crotonaldehyde) for example are produced during 1 s and therefore found in all types of smoke including cigarette s \[2, 10\]. 2-Propenal is pre sent at 25 – 140 ptrhoveidredmbyoorbestetfriociarnms ed ary care) and academic 1 15\]. Lipid peroxi roperoxides as tem is risk selection. Risk ly referring women and veloping complications to d e s g e n e r a p ciple behind risk selection me paosltnoatnaldpeiraiodldarehinyde\[ ing low risk pregnancies, care, and only cases of ternity care, the various o its full potential \[11\]. To to dications (Verloskundige d \[co1ns4en\]sus among the hird revision of this list, Structure aternity care, with the main care providers. lands provide this type of pregnadnt wombenyin theob eck-up in a primary care ed e h y in ro fess io na ls se r ve as a n d co nsult a t te d labo ur in pr imar y care, d e s l i s regnancy (prenatal care), are) and um care). women from pregnancy consists of an intake and ng and health education ds of the Royal Dutch (intake) should ideally be Throughout pregnancy 10 rage of 13, depending on ns of clients. In the first s risk sele erring 9w ion o f te san μg/cigarette endogenousl dation,initisure acrol in the gas y by lipid ated by a l reaction gradation Pagina afloop Expo 2-Propenal ( α,β-unsaturation combustion o smoke and ex Paginarand with the ources d wine \[1\], bacco smoke a\] n s Cinna deriva and aroma su al d wine \[1\], 1 mic bacco smoke \] anana \[1\], fig 7\] rape, orange \]isk Skilled pro childbirth, Gener bstituted 2- wi ad Zwarte balk t.b.v. trapeffect wi dehydes 2-phenyl-2-alke al I roducti H fessional car but also during n n -b 3- ad do T co do wi n zijkant boek eterocyclic i for pregnFaurnfutralwdeormivaet o major initia umber of de 16\]. accordance in f org ring/side chain haus phase of the smok peroxidation of p free-radical chain products. Subsequ products including Table 1.1 Examp more comcaptegloerixes made b Description of the Alphatic acade alkyla th or dition ction. R en S retivesCinnamylaldeh ta stetrici\[2ticalkyl to double- ta \[2 b \[1 g n \[1 omen caucnumdber\[18\] -c on ing complications to period, professional care is generally acknowledg 21-02-15 18:47 adverse pregnancy outcomes, and it is considered myl With or addition the prenatal and po Furanswith conjugation in side no y n- n double- con d re other a ds alkyla th or dition uble- wo or njuga uble- thout on v e ydes also comes from other sources than the diet. otonaldehyde) for example are produced during Alicyclic Cinnamyl derivatives and other aromatic alkyl substituted aldehydes Heterocyclic Others 1.3 General introduction 1 General Introducti Skilled professional ca cpheirlidobdi,rtphr,obfeustsioalnsaol cdaur adverse pregnancy outc treating complications, lifestyle and facilitating care is necessary to m ha-1,8-dien-7- α,β-unsaturation in side chain α,β-unsaturation in ring/side chain more complex Cinnamyl aldehyde Furfural derivatives Furfural ore found inWord p-mentha-1,8(10)-die n-9-al p-mentha-1,8-dien-7- al 2,6,6-trimethylcycloh exa-1,3-diene-1- carbaldehyde trans-cinnamaldehyd e all types ropenal is present at 25 – 140 μg/cigarette in the gas of ehydes are furthermore formed endogenously by lipid smo ke including cigarette (PUFAs) \[2, elds lipid hydroperoxides as major initial reaction d hydroperoxides generates a number of degradation 15\]. Lip id pe ro xidation, initiated by a graphic alkenals, and malondialdehyde \[16\]. imethylcycloh y replaced graphic saturated aldehydes listed in accordance with the tural similarity \[14\] -diene-1- e ehyde acrolein) Structure -nonadie Sources red wine \[1\], tabacco smoke \[2\] red wine \[1\], tabacco smoke \[2\] banana \[1\], fig \[17\] grape, orange \[1\] cucumber \[18\] black tea \[19\] lime \[1\] cassia (bark oil) \[1\] n namaldehyd 2-phenyl-2-alkenals cassia ( rk nal de) x 5-methyl-2-phenylhe b a nal al cacao, coffee, -2 oil) \[1\] -e onaldehy yl-2-phenylhe l re of anial) -4-hexad yl-2-pete foster an environment t meat prodaus cwtsell as social and \[21\] Furthermore, it offers n that come with it \[2\]. D prenatal and postnat demonstrated that no likely to make inadequa Research conducted so non-western women’s Filling this gap in knowl conducting this study. interactions between n involved, as this may aff Furans with conjugation in side chain Furfurylidene-2-buta nal Other sulphur 2-(Methylthiomethyl) containing substances -3-phenylpropenal ADME (absorption, distribution, metabolism and excretion) a fig \[17\], α,β-Unsaturated aldehydes are rapidly absorbed, distributead, nmetdabolizesd pandexcreted liniusriene, re, blueberry\[20\] faecesandexpiredacir.aWchaenom,alceoWfisftaerera,tswereexpo 14 theaim,researchquest This introductory chapt population density ia d ‘cli in this thesis. ty c non-western women in Or ma among non-western wo terni the no lnly important during riod. In the prenatal -4-octad ffective in preventing lidene-2-buta ctive in detecting and 10 l trans-2-nonenal or trans-2-pentenal by gavage \[22\], both aldehydes entered the systemicary ca circulation from the mgasteroaintesptinraol (dGIu) tcratcst, and were metabolized to yield C-3 mercapturic acids within 24 hours. Only trace amount of trans-2-nonenal or trans-2-pentenal were foundIninthe Netherlands, mat primary, secondary and faeces \[22\]. In anoth\[er2st1ud\]y, male and female Sprague-Dawley rats were exposed to 2.5 or 15 midwives, autonomous mg/kg bw 14C labelled 2-propenal by gavage \[23\]. Urine was the major excretion rocuatre on their own acc active in midwifery car sed to 100 m g/ C el led kg bw of hospitals (tert One of the basic pil 811 selection is condu ab g anis ati on of ma te on re for pregnant women is ring the prenatal and postn e is generally acknowledged omes, and it is considered to providing timely interven informed choice \[1\]. In the aintain and promote the he hat offers help and support f cultural issues that can a ew parents support for pare espite these advantages and al care, previous studies n-western women from vari te use of these services \[3-7\]. far, has not been able to give prenatal and postnatal care edge and understanding pr The second rationale w on-western women and the ect the utilisation of prenatal \[er9prov\]ide.s bacSkgroeundcinfor n- men and the utilisation of p ions wes ntheiNcethaerlalnd’s. In amdditio a heo re tical fr , perin amew ter nd t n pop ula tion rrnitey ca)re in\[th1e N0ethe\]rl.an ernity care is organised in a tertiary care \[8\]. Primary car qualified medical professio ountability, and a small nu e. Latter are mainly engag lars of t cted at Non-western wo PDF o 1 grafische òf kopteks Meerdere population density \[9\]. Secondar and specialised ‘clinical’ midwiv hospitals (tertiary care) \[10\]. Os e n l e e c o t i f o n t h e i s b a c s o i n c d p u i l c l a t e r s d o a f t t h p e r i D m u ata(l ccraoretoenncoamlpdaesshesysdupe)rvision of pregnant irmationduringtheprenatalperioduntilbirth.Ittedaldehydesmaternitycareprofessionalsabovementionedprimarycare € 400,- a t u r a e lat io n d en s ity \[9\] .S e co nd ar y an d tert ia ry ca u r ital s a t t y a c i d s (PUFAs) \[2, f (te r ti ary c ar e) \[ 10 \]. t d a l d e h y specialised ‘clinical’ midwives in general (second d e s a r e f re is chanism, yields lipid hyd of the basic pillars of the Dutch maternity care sys een ction is conducted at primary care level by on borns with complications or an increased risk for de i t i o n o f l i p i d h y n keepers to secondary maternity care. The basic prin d a ry c are. T hu s lan t he s pr ep rim a cy d r o p e r o x i ry ,c m nal ted aldehydes 2-methylcrot ary2m-bidwuitferyncalre includes care provided during p l (secondary c birth(natalcare)andafterbirth(postnatal/postpartlsutilisationintheNetherlands.publishedin2003,isinuse. without de 5-meth al double trans-2-meth nal ovided the main rationale for x-2-ena as gaining insight into the This thesis is specifically focu nFou ien al a tal a nd m ate rna l mort ality tting. E ven tuall y, 5 4.3% o ft he nd tertiary care is n, information is given about ork of the research presented Primary midwifery care includes idwives in general (secon is2-kmefthoylcrrotdonealdvehey lop de Furfury to bnealeffe primary care level by o s secondary care. Thus these primary maternity car gatekeepers to secondary maternity care. The basic pri nity care professionals serve as timely 3 2429 Boerlei der.indd 9 trans-2-methyl-2-pete lifestyle and facilitating informed chOotihceer s\[u1lp\]h.uIrn the po2s-(tMneatthaylthpioemreiothdyl)professional black tea \[19\] treating complications, providing chain interventions, promoting a healthy newborns with complications or an increa e d risk for d nal containing substances -3-phenylpropenal asic principle behind risk selection care is necessary to maintain and promote the health of mother and child, to Others 32620 Reiko Kiwamoto.indd 11 17-03-15 15:34 s trans-2-trans jug a bonds ted ds model consisting of so called e is provided by primary care nals providing full maternity mber of general practitioners ed in rural areas with a low men in maternity care in the Netherlands Chapter 1 D fi o r sp p u l u d s 4t h b d o v h y a y e b th and the postnatal period are in foster an environment that offers help and support for physical and mental health g m p n e DF opmaak standaard 175,- PDF op n is that in the Netherlands, pregnancy, childbirth and th