Page 92 - Migraine, the heart and the brain

Chapter 5
Table 3. Risk factors for migraine
Variables
Aortic root replacement (n = 103)
Marfan syndrome (n = 123)
Female gender (n = 133)
Migraine without aura OR (95% CI)
2.8 (0.9–8.5) 2.5 (0.7–8.8)
4.7 (1.7–13.3)
p-value Migraine with aura OR (95% CI)
0.07 3.1 (1.2–8.0) 0.2 2.5 (0.9–7.1)
0.003 3.6 (1.6–8.2)
p-value No migraine
0.02 1.0 (referent) 0.08 1.0 (referent)
0.03 1.0 (referent)
The predictors for migraine without aura and migraine with aura, adjusted for age using a multinomial logistic regression model using aortic root replacement, Marfan syndrome and gender as independent variables. No migraine was set as referent.
OR: odds ratio, 95% CI: 95% con dence interval.
A total of 117 Dutch MFS patients were invited to participate in a general health interview and 47 MFS patients in Copenhagen were re-invited to participate in an interview on AR. A total of 123 of 164 invited MFS patients participated (response rate 75%, n = 33 Danish, n = 90 Dutch). A total of 60 non-MFS patients with AR were invited and of these 51 participated (response rate 85%). Eighty-two controls were provided by MFS patients and all 82 controls participated.
The demographic characteristics of the study population are summarised in Table 1. MFS patients with AR were slightly older than MFS patients without AR. Age when AR was performed was lower in MFS patients when compared to non-MFS patients.
Lifetime migraine prevalence was increased in female MFS patients (51%) compared to healthy female controls (29%), p = 0.017 (Table 2). In males lifetime migraine prevalence was only numerically increased. Lifetime migraine with aura prevalence was increased among MFS patients compared to healthy controls both in males (19% vs. 3%, p = 0.048) and females (30% vs. 14%, p = 0.049). Migraine without aura prevalence was not increased in Marfan patients. In non-MFS patients with AR, migraine prevalence compared to healthy controls was not signi cantly increased.
Table 4. Characteristics of migraineurs among groups, strati ed for aortic root surgery
Variables
Mean age at onset migraine (SD)
Mean age at onset migraine with aura (SD) Visual aura duration, minutes (SD) Lifetime high attack frequency (%)
MFS
(n = 27)
20 (11) 19 (10) 24 (8) 8 (29)
Non-MFS (n = 13)
18 (17) 19 (18) 52 (46) 4 (31)
MFS (n = 23)
17 (6) 16 (5) 63 (105) 11 (48)
Controls (n = 21)
21 (12) 18 (5) 33 (22) 10 (51)
Aortic root surgery
No aortic root surgery
MFS: Marfan syndrome; non-MFS: non-Marfan syndrome with aortic root replacement; SD: standard deviation. Values are presented as means (SD). Lifetime high attack frequency > 3 attacks/ month.
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